Day 1 :
- Pediatrics | Pediatric Cardiology | Neonatology
K. M. Yacob is a practicing physician in the field of healthcare in the state of Kerala in India for the last 30 years and very much interested in basic research. His interest is spread across the fever, inflammation and back pain. He is a writer. I already printed and published nine books on these subjects. He wrote hundreds of articles in various magazines. After scientific studies, we have developed 8000 affirmative cross checking questions. It can explain all queries related to fever.
Marma Health Centre, India
Tyumen State Medical University, Russia
In 2013, she defended her dissertation at the age of 40. She has 24 publications in famous scientific journals. She is currently working as an assistant professor at the Department of Pediatric Diseases at the Pediatric Faculty of Tyumen State University.
Background: Destabilization of cardiac myocyte cell membrane, its structure and function influences on the development of sinus bradycardia (SB).
Purpose: To study total cholesterol (TC) of platelet membrane as cardiac myocyte model, total intracellular calcium (Ca2+) in platelets in children with SB without organic heart disease depending on the clinical variant and with autonomic dystonia syndrome (ADS) and idiopathic (asymptomatic) syndrome.
Methods: Children aged 3-13 years matched by sex and age were divided into three groups: group 1 consisted of healthy children (control group, n=30), group 2 consisted of children with idiopathic SB (n=20) and group 3 consisted of children with SB and ADS. Diagnostic tests and procedures were carried out. Special methods included TC and Ca2+ in platelets.
Results: TC volume in platelets of children in group 2 was significantly higher than TC volume in healthy children for 1.8 times, in group 3 – for 2.3 times (p<0.05). Besides, parameters of group 3 were definitely higher than values of group 2 (0.34±0.23 vs 0.27±0.15 mcM/ml, respectively, p <0.05). Decrease of Ca2+ in children with SB was revealed. The value of Ca2+ in children of group 2 showed significant lowering (0.05±0.009 mcM/ml, p<0.05) in comparison with healthy children (0.09±0.009 mcM/ml, p<0.05).
Conclusion: Elevated cholesterol level in the platelet membrane can be estimated as membrane destabilizing factor, altering electrochemical potential of the cell, lowering fluidity of the platelet cell membranes; it may serve as differential and diagnostic criteria of idiopathic SB with ADS. As calcium is the key regulator of several important cell functions, change of Ca2+ concentration in the citosol leads to misbalance of the intracellular processes; it may serve as the marker of idiopathic SB.
Addenbrooke’s Hospital, UK
Deepa is presently working as a Consultant Pediatric Neurologist, Addenbrooke’s Hospital, UK
Pediatric Idiopathic intracranial hypertension (also called Pseudotumor cerebri syndrome- PTCS) is a rare disorder in children with incidence of 1-3 increasing to 12/28 per 100,000 based on various population groups. It is frequently considered as a diagnosis in children with headaches, papilloedema, high BMI with normal MRI and CSF investigations. The presentation of this condition is varied and no standard national or international guideline exists that help with diagnostic criteria and management. There are no randomised controlled trial for the treatment of this condition in children. The children are cared for by Pediatric neurologists, Pediatricians, Ophthalmologists, ENT specialists and Neurosurgeons. The talk aims to give an overview of the new insights in the condition, pitfalls in the diagnosis and management of the condition with personal experience from the team at Addenbrooke’s Hospital, Cambridge, UK.